Cephalosporins (CPC) antibiotics are among the most important β-lactam antibiotics. They are mainly used to treat a variety of severe bacterial infections, such as those in the respiratory tract, on the skin, and in urinary tract infections. 7-ACA obtained through the synthesis of cephalosporins is a crucial intermediate, from which four types of cephalosporins antibiotics can be synthesized. Jiangsu Kingshan can provide all resin products required for the purification of cephalosporins to the preparation of 7-ACA.

After the fermentation broth is separated by microfiltration or ultrafiltration, the biomass and antibiotics obtained will undergo further impurity removal and decolorization through Bestion® BJ7511. Then, cephalosporins (CPC) will be adsorbed by Bestion® BJ7505. The solution obtained after desorption will enter Bestion® PC764 (usually in the acetate form) to remove the residual color. After purification, CPC undergoes a two-step reaction with D-amino acid oxidase and glutaryl acylase to obtain 7-ACA. It's worth noting that the enzymatic reaction in the acylation process can be replaced by immobilized enzymes. Jiangsu Jinshan provides the Bestion® ECR series of enzyme carrier products, which possess stable enzyme activity and strength.

As for the adsorption step where Bestion® BJ7505 is used, there are many alternative products, such as Bestion® BJ7507, Bestion® BJ7506, and Bestion® BJ7509. Among them, some can provide a higher adsorption capacity in many fermentation systems. In strongly hydrophobic systems, Bestion® BJ7504 is the optimal choice.

In conclusion, the preparation of cephalosporins antibiotics is a complex and delicate process. The series of products provided by Jiangsu Kingshan offer strong support for its industrial production and ensure a continuous supply of these crucial antibacterial drugs in the medical field.