I. Product Introduction

The main mechanism of action of AP268 revolves around bile acid metabolism. Bile acids, as metabolic products of cholesterol, are normally efficiently reabsorbed in the jejunum and ileum. When AP268 enters the human body, it significantly increases the excretion of bile acids, capable of increasing their excretion by up to ten times. To compensate for the significant loss of bile acids, the liver will convert more cholesterol into bile acids through the 7α-hydroxylation process. At the same time, the low-density lipoprotein (LDL) receptors in the liver are upregulated, thereby increasing the uptake of LDL cholesterol and intermediate density lipoprotein (IDL) in the plasma, ultimately achieving the effect of reducing cholesterol levels in the blood.

II.Case Applications

1. Treatment of Hypercholesterolemia: In numerous clinical cases, Jiangsu Jinshang's AP268 has demonstrated excellent performance in the treatment of hypercholesterolemia. The company can produce drugs using AP268 to treat primary hypercholesterolemia and prevent LDL cholesterol levels from remaining high for an extended period. After a month of treatment following the combination of dietary control and therapy, the LDL cholesterol level decreased by 15%, and after three months, the decrease reached 18%. During the subsequent long-term treatment, the cholesterol level remained within a relatively ideal range, significantly reducing the risk of cardiovascular diseases.

2. Diabetes Complicated with Dyslipidemia: In a randomized, double-blind crossover study involving 21 patients with dyslipidemia and type 2 diabetes, patients took the drug made from AP268 as the raw material. Within one week, the plasma glucose level decreased by 13%. This indicates that AP268 not only reduces cholesterol but also has a positive impact on the glucose metabolism of diabetic patients. For patients with both diabetes and dyslipidemia, Jiangsu Jinshang's AP268 provides an effective combined treatment option, which can simultaneously improve blood sugar and lipid conditions and reduce the overall risk of cardiovascular diseases.